Tocopherol succinate (CAS 4345-03-3) is a potent antioxidant that protects mice from gamma radiation by inducing granulocyte-colony stimulating factor. It induces apoptosis in human gastric cancer cells, inhibits the proliferation of mesothelioma cells through down-regulation of fibroblast growth factor receptor-1 (FGFR-1), and also promotes apoptosis in neuroblastoma cells.
D-α-Tocopherol succinate Chemical Properties
| Melting point | ~76 °C(lit.) |
| Boiling point | 625.8±55.0 °C(Predicted) |
| Density | 1.002±0.06 g/cm3(Predicted) |
| Vapor pressure | 0Pa at 20℃ |
| Storage temp | -20°C |
| Solubility | Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol. |
| Form | Solid |
| Pka | 4.35±0.17(Predicted) |
| Color | White or off-white |
| Odor | Little or no odor |
| Biological source | synthetic |
| λmax | 286nm(EtOH)(lit.) |
| Merck | 14,9495 |
| BRN | 4038233 |
| Specific Activity | 1210IU/g |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| LogP | 12 at 25℃ |
| CAS DataBase Reference | 4345-03-3(CAS DataBase Reference) |
| EPA Substance Registry System | D-.alpha.-Tocopheryl acid succinate (4345-03-3) |
Safety Information
| WGK Germany | 1 |
| RTECS | EJ9984000 |
| F | 8-10-23 |
| HS Code | 2936280000 |
| Toxicity | LD50 oral in rat: > 7gm/kg |
A potent and novel antineoplastic agent with high selectivity that works cooperatively with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits the proliferation of mesothelioma cells through selective down-regulation of fibroblast growth factor receptors and has been shown to enhance the antitumor effects of dendritic cell vaccines.
