Product Description of 2‑Deoxy‑D‑Glucose (CAS# 154‑17‑6)
2‑Deoxy‑D‑glucose functions as an antimetabolite competing against D‑glucose. It is capable of disrupting the biosynthesis of viral glycoproteins and suppressing the multiplication of herpes simplex virus, enveloped RNA and DNA viruses, together with tumor cells.
At present, antiviral and antitumor candidates derived from this compound are available for clinical intervention targeting herpes simplex infections and malignancies. Besides pharmaceutical uses, commercial formulations including health supplements and anti‑aging cosmetics fortified with 2‑deoxy‑D‑glucose have already been launched.
This biochemical agent features a benign toxic profile without notable adverse reactions. Such safety characteristics enable its broad utilization across healthcare goods, anti‑aging skincare preparations and life science research work. It also carries remarkable commercial value and holds bright prospects for further exploitation.
2-Deoxy-D-glucose Chemical Properties
| Melting point | 146-147 °C(lit.) |
| Alpha | 45.5 º (c=2, H2O) |
| Boiling point | 211.61°C (rough estimate) |
| Density | 1.1738 (rough estimate) |
| Refractive index | 46.5 ° (C=1, H2O) |
| Storage temp | 2-8°C |
| Solubility | H2O: 50 mg/mL, clear, colorless to faintly yellow |
| Form | crystalline |
| Pka | pK1:12.52 (25°C) |
| Color | white |
| Water Solubility | Soluble in water. |
| Merck | 142904 |
| BRN | 1723331 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used within 1 working day. |
| InChIKey | PMMURAAUARKVCB-CEZCPVKQSA-N |
| LogP | -1.460 (est) |
| CAS DataBase Reference | 154-17-6(CAS DataBase Reference) |
| EPA Substance Registry System | D-arabino-Hexose, 2-deoxy- (154-17-6) |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 24/25-37/39-36-26 |
| WGK Germany | 3 |
| RTECS | MQ3325000 |
| F | 46091 |
| TSCA | Yes |
| HS Code | 29400090 |
| Hazardous Substances Data | 154-17-6(Hazardous Substances Data) |
Product Application of 2‑Deoxy‑D‑Glucose (CAS# 154‑17‑6)
As a D‑glucose derivative acting as an antimetabolite, 2‑deoxy‑D‑glucose interacts with the envelope architecture of orthomyxoviruses, paramyxoviruses and herpes viruses. It blocks the biosynthesis of unique viral glycoproteins and delivers potent inhibitory effects on the replication of herpes simplex virus, enveloped RNA and DNA viruses, as well as breast carcinoma cells.
Pharmaceutical candidates built on this compound for antiviral and antitumor purposes are under clinical investigation for herpes simplex infections, influenza, AIDS and various cancers. Meanwhile, finished anti‑aging skincare items and nutritional supplements incorporating this raw material have been commercialized.
Given its promising value in antiviral regimens, tumor therapy and anti‑aging formulations, 2‑deoxy‑D‑glucose enjoys expansive application room and sustained market demand.
