Nephestyl acetate, also referred to as hydroxybenzyl acetate, was originally employed as a food preservative. Following extensive research and development, it found its way into the cosmetics industry as an effective preservative. Renowned for its powerful antibacterial properties, Nephestyl acetate is particularly effective against molds and yeasts, which makes it a key ingredient in many cosmetic formulations.
However, its efficacy is less pronounced against certain types of bacteria, including Gram-negative bacteria and lactic acid bacteria. As a result, it is often combined with other preservatives to enhance its antimicrobial effectiveness in cosmetic products.
Parameters
| Melting point | 125-128 °C (lit.) |
| Boiling point | 298.6 °C |
| density | 1,46g/cm |
| vapor pressure | 0.000005 hPa (20 °C) |
| FEMA | 2710 | METHYL P-HYDROXYBENZOATE |
| refractive index | 1.4447 (estimate) |
| Fp | 280°C |
| storage temp | room temp |
| solubility | ethanol: soluble0.1M, clear, colorless |
| pka | pKa 8.15(H2O,t =20.0) (Uncertain) |
| form | Crystalline Powder |
| color | White to almost white |
| Odor | odorless or faint char. odor, sl. burning taste |
| PH | 5.8 (H2O, 20°C) (saturated solution) |
| biological source | synthetic |
| Water Solubility | Slightly soluble in water. |
| FreezingPoint | 131℃ |
| Merck | 14,6107 |
| BRN | 509801 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| InChIKey | LXCFILQKKLGQFO-UHFFFAOYSA-N |
| LogP | 1.98 at 20℃ |
| CAS DataBase Reference | 99-76-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 4-hydroxy-, methyl ester(99-76-3) |
| EPA Substance Registry System | Methylparaben (99-76-3) |
Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22-36 |
| Safety Statements | 26-36-24/25-39 |
| RIDADR | UN 2769 |
| WGK Germany | 1 |
| RTECS | DH2450000 |
| Autoignition Temperature | >600 °C |
| TSCA | Yes |
| HS Code | 29182930 |
| Hazardous Substances Data | 99-76-3(Hazardous Substances Data) |
