Twain 80 is a synthetic non-ionic emulsifier extensively utilized in the cosmetics, food, and pharmaceutical industries. The manufacturing process involves alkaline catalysis, where ethylene oxide reacts with sorbitol fatty acid esters and sorbitan fatty acid esters. In this reaction, each mole of sorbitol or its corresponding sorbitan anhydride reacts with 20 moles of ethylene oxide. Originally developed by the American company ICI, "Twain" is the brand name ICI gave to this class of emulsifiers. Different product numbers, such as Twain 60 and Twain 80, are used to specify the fatty acids involved in the synthesis.
Parameters
Melting point | -25 °C |
Boiling point | >100°C |
density | 1.08 g/mL at 20 °C |
vapor pressure | <1 mm Hg ( 20 °C) |
refractive index | n |
FEMA | 2917 | POLYSORBATE 80 |
Fp | >230 °F |
storage temp. | -20°C |
solubility | DMSO (Soluble), Methanol (Slightly) |
form | viscous liquid |
color | Amber |
Specific Gravity | 1.080 (25/4℃) |
PH Range | 6 |
Odor | mild alcoholic |
PH | 5-7 (50g/l, H2O, 20℃) |
Odor Type | alcoholic |
biological source | synthetic |
Water Solubility | 5-10 g/100 mL at 23 ºC |
Merck | 14,7582 |
Hydrophilic-Lipophilic Balance (HLB) | 10 |
LogP | 4.392 (est) |
EPA Substance Registry System | Polysorbate 80 (9005-65-6) |
Safety Information
Hazard Codes | Xi |
Risk Statements | 22-36/37/38-37/38-41 |
Safety Statements | 24/25-36/37/39-36-26 |
WGK Germany | 1 |
RTECS | WG2934000 |
F | 3 |
TSCA | Yes |
HS Code | 34021300 |
Hazardous Substances Data | 9005-65-6(Hazardous Substances Data) |
Toxicity | LD50 in mice, rats (ml/kg): 7.5, 6.3 i.p. (Varma) |
Emulsifiers; Pharmaceutical excipients; Non-ionic surfactants; Industrial surfactants; Chemical auxiliaries; Organic solvents; Organic chemical products; Food additives; Other organic reagents; Biochemical reagents; Surfactants; Pharmaceutical intermediates; Detergents; Microorganisms; Various chemical reagents; Solvents; Inorganic compounds and salts; Organic chemical industry products; Organic lithium compounds and organic bases; Organic chemical raw materials; Intermediates; Biochemistry; Non-ionic surfactants for biochemistry; Cosmetic ingredients and chemicals; Detergents; Emulsifiers; Reagents and supplements; Tween; Biochemical reagents – surfactants; Organic chemical raw materials; Raw materials; Daily chemical raw materials; Other raw materials; Biochemical reagents – amino acids; Dye additives and other chemical additives – dye additives; Additives; Chemical materials.
