Calcium pantothenate, also referred to as calcium D-pantothenate or calcium pantothenic acid, is a natural form of pantothenic acid, an essential vitamin present in many foods. It is classified as Generally Recognized as Safe (GRAS) in both the United States and Europe. According to FDA regulations, infant formulas must contain no less than 300 micrograms (mcg) per 100 calories of the prepared product.
Calcium D-Pantothenate Chemical Properties
| Melting point | 190 °C |
| Alpha | 26.5 º (c=5, in water) |
| Refractive index | 27 ° (C=5, H2O) |
| Fp | 145 °C |
| Storage temp | 2-8°C |
| Solubility | H2O: 50 mg/mL at 25 °C, clear, nearly colorless |
| Form | Powder |
| Color | White or almost white |
| PH | 6.8-7.2 (25℃, 50mg/mL in H2O) |
| Odor | Odorless |
| Biological source | synthetic (organic) |
| Optical Rotation | [α]20/D +27±2°, c = 5% in H2O |
| Water Solubility | Soluble in water |
| Sensitive | Hygroscopic |
| Merck | 14,7015 |
| BRN | 3769272 |
| Stability | Stable, but may be moisture or air sensitive. Incompatible with strong acids, strong bases. |
| InChIKey | FAPWYRCQGJNNSJ-UBKPKTQASA-L |
| LogP | -0.849 (est) |
| CAS DataBase Reference | 137-08-6(CAS DataBase Reference) |
| EPA Substance Registry System | Calcium pantothenate (137-08-6) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-37/38-41-48 |
| Safety Statements | 24/25-45-36/37/39-26-22 |
| WGK Germany | 1 |
| RTECS | RU4375000 |
| F | 3-10 |
| TSCA | Yes |
| HS Code | 29362400 |
It is used in biochemical research as a nutrient component of tissue culture media. Clinically, it is applied in the treatment of vitamin B deficiency, peripheral neuritis, and postoperative colic.
It serves as a food fortifier and is also added to infant food at a dosage of 15–28 mg/kg, while beverages typically contain 2–4 mg/kg.
