L-Methionine is a sulfur-containing essential L-amino acid crucial for numerous bodily functions. It is a dietary indispensable amino acid necessary for the normal growth and development of humans, other mammals, and birds. Beyond serving as a substrate for protein synthesis, L-Methionine also acts as a key intermediate in transmethylation reactions, functioning as a primary methyl group donor.
L-Methionine Chemical Properties
| Melting point | 284 °C (dec.)(lit.) |
| Alpha | 23.25 º (c=2, 6N HCl) |
| Boiling point | 393.91°C (estimate) |
| Density | 1,34g/cm |
| Bulk density | 550kg/m3 |
| Refractive index | 1.5216 (estimate) |
| Storage temp | 20-25°C |
| Solubility | 1 M HCl: 0.5 M at 20 °C, clear, colorless |
| Pka | 2.13(at 25℃) |
| Form | Solid |
| Color | White |
| Odor | Slight characteristic |
| PH | 5-7 (10g/l, H2O, 20℃) |
| Biological source | Synthetic |
| Optical Rotation | [α]20/D +23.7±0.5°, c = 5% in 5 M HCl |
| Water Solubility | Soluble |
| λmax | λ: 260 nm Amax: 0.40 λ: 280 nm Amax: 0.05 |
| Merck | 14,5975 |
| BRN | 1722294 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | 0.217 (est) |
| CAS DataBase Reference | 63-68-3(CAS DataBase Reference) |
| NIST Chemistry Reference | L-Methionine(63-68-3) |
| EPA Substance Registry System | L-Methionine (63-68-3) |
Safety Information
| Risk Statements | 33 |
| Safety Statements | 24/25 |
| WGK Germany | 2 |
| RTECS | PD0457000 |
| F | 10-23 |
| TSCA | Yes |
| HS Code | 29304010 |
| Hazardous Substances Data | 63-68-3(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 36gm/kg |
Used as amino acid drugs and nutritional supplements, L-methionine is applied in the treatment of fatty liver and cirrhosis. It is also widely used as a feed additive to enhance feed quality, improve the utilization of native protein, and promote animal growth. For example, DL-methionine can increase egg production in chickens, support weight gain in pigs, and boost milk yield in cows.
