Sodium butyrate is a white crystalline solid with a strong, unpleasant odor, naturally present in butter and animal fat in the form of glycerol esters. It is the sodium salt of butyric acid and exhibits multiple biological effects on cultured mammalian cells, including the inhibition of proliferation, induction of differentiation, and the ability to either induce or repress gene expression.
Sodium Butyrate Chemical Properties
| Melting point | 250-253 °C (lit.) |
| Density | 1.324 g/cm3 (30℃) |
| Storage temp | Store below +30°C. |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Form | Amorphous Powder |
| Color | White |
| Biological source | Synthetic (organic) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 3629439 |
| Stability | Stable. Incompatible with strong acids. |
| InChI | InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1 |
| InChIKey | MFBOGIVSZKQAPD-UHFFFAOYSA-M |
| SMILES | C(CC)C([O-])=O.[Na+] |
| LogP | 0.777 (est) |
| CAS DataBase Reference | 156-54-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Sodium butyrate(156-54-7) |
| EPA Substance Registry System | Butanoic acid, sodium salt (156-54-7) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-68 |
| Safety Statements | 37/39-26-24/25-36/37 |
| RTECS | ET6400000 |
| F | 3-10 |
| HS Code | 29156000 |
| Hazardous Substances Data | 156-54-7(Hazardous Substances Data) |
Sodium butyrate functions as an inhibitor of histone deacetylase (HDAC) activity, contributing to the improvement of physiological disorders such as Duchenne muscular dystrophy. Additionally, when combined with other cytotoxic agents, it shows potential as an antitumor agent in the treatment of carcinomas.
