Products Description of Tetramethylguanidine (CAS#80‑70‑6)
Tetramethylguanidine, abbreviated as TMG, represents a potent organic base catalyst with extensive industrial adoption. One major application is acting as a co‑solvent during the synthetic routes for novel cephalosporin antibiotics.
Beyond this pharmaceutical use, TMG works as a catalytic agent for polyurethane foam fabrication. It is also introduced into the dyeing procedure for nylon, wool and other protein‑rich fibers. This additive promotes even color distribution and strengthens the long‑lasting performance of textile substrates.
Tetramethylguanidine Chemical Properties
| Melting point | -30 °C |
| Boiling point | 162-163 °C (lit.) |
| Density | 0.916 g/mL at 20 °C (lit.) |
| Vapor pressure | 0.2 mm Hg ( 20 °C) |
| Refractive index | n20/D 1.469 |
| Fp | 140 °F |
| Storage temp | Store below +30°C. |
| Solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Pka | 15.20±0.70(Predicted) |
| Form | Liquid |
| Color | APHA: ≤150 |
| PH | 12.7 (10g/l, H2O, 25℃) |
| Relative polarity | 5.5 |
| Odor | mild ammoniacal odor |
| Explosive limit | 1.0-7.5%(V) |
| Water Solubility | miscible |
| Sensitive | Air Sensitive |
| BRN | 969608 |
| Dielectric constant | 23.1 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide. Air-sensitive. |
| InChIKey | KYVBNYUBXIEUFW-UHFFFAOYSA-N |
| LogP | -0.49 at 20℃ |
| CAS DataBase Reference | 80-70-6(CAS DataBase Reference) |
| NIST Chemistry Reference | N,N,N',N'-Tetramethylguanidine(80-70-6) |
| EPA Substance Registry System | Guanidine, N,N,N',N'-tetramethyl- (80-70-6) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 22-34-20/22-10 |
| Safety Statements | 26-27-36/37/39-45-16 |
| RIDADR | UN 2920 8/PG 2 |
| WGK Germany | 1 |
| F | 46288 |
| Autoignition Temperature | 222 °C |
| Hazard Note | Harmful/Corrosive |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29252000 |
| Toxicity | LD50 orally in Rabbit: 835 mg/kg |
Product Application of Tetramethylguanidine (CAS#80‑70‑6)
Tetramethylguanidine acts as a powerful organic base catalyst and auxiliary solvent for preparing new antibiotic compounds, with prominent usage in cephalosporin drug synthesis. It also works as a catalytic additive during polyurethane foam manufacturing. Within textile processing, this chemical assists level dyeing for nylon, wool and other protein‑based fibers, delivering consistent coloration and better wear resistance for wool goods. Besides the above scenarios, it is a key material for the synthesis of pharmaceutical molecules including cefradine.
