Products Description of Musk Ketone (CAS# 81‑14‑1)
Musk Ketone represents a vital synthetic aroma‑chemical possessing the molecular formula C₁₄H₁₈N₂O₅ with a molecular weight of 294.303. It occurs as pale‑yellow crystalline powder or flaky solids, distinguished by a sweet, animal‑toned musk fragrance that carries soft character and exceptional tenacity.
This substance cannot dissolve in water or 2‑(2‑tert‑butylaminoethoxy)ethanol, yet dissolves readily in benzyl benzoate, animal‑derived oils and diverse essential oils. Its physicochemical parameters include a melting range of 135‑139 °C, approximate density of 1.2 ± 0.1 g/cm³, boiling‑point value of 369.0 ± 42.0 °C (at 760 mmHg), together with a flash point measured at 153.2 ± 20.7 °C.
| Product Name: | Musk ketone |
| Synonyms: | 2-Acetyl-5-tert-butyl-4,6-dinitro-1,3-dimethylbenzene;3',5'-Dinitro-4'-tert-butyl-2',6'-dimethylacetophenone;3, 5-Dinitro-4-t-butyl-2, 6-dimethylacetophenone;Ketone Moschus,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Musk ketone;Musk ketone,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Ketone Moschus;Musk ketone 0;Ketone Moschus >=97.0% (N);1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)-ethanon |
| CAS: | 81-14-1 |
| MF: | C14H18N2O5 |
| MW: | 294.3 |
| EINECS: | 201-328-9 |
| Product Categories: | PP;KetonesAlphabetic;Analytical Standards;AromaticsAnalytical Standards;Chemical Class;Life Sciences Standards;Aromatic Acetophenones & Derivatives (substituted);M;METI - MZChromatography;Natural Compounds;Natural CompoundsAnalytical Standards;Nitro CompoundsChemical Class;OtherMore...Close...;Cosmetics;Food & Feed ADDITIVES;Organics |
| Mol File: | 81-14-1.mol |
Musk ketone Chemical Properties
| Melting point | 134-137 °C |
| Boiling point | 436.08°C (rough estimate) |
| Density | 1.2051 (rough estimate) |
| Vapor pressure | 0.001Pa at 25℃ |
| Refractive index | 1.5110 (estimate) |
| Fp | 2 °C |
| Storage temp | 2-8°C |
| Solubility | DMSO : 250 mg/mL (849.47 mM; Need ultrasonic) |
| Form | Solid |
| Color | White to off-white |
| Odor | at 10.00 % in benzyl benzoate. fatty musk soapy dry floral powdery |
| Odor Type | musk |
| Biological source | synthetic |
| Water Solubility | Insoluble (<0.1 g/100 mL at 20 ºC) |
| BRN | 2062638 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| InChIKey | WXCMHFPAUCOJIG-UHFFFAOYSA-N |
| LogP | 4.24 at 25℃ |
| CAS DataBase Reference | 81-14-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,6-Dimethyl-3,5-dinitro-4-t-butylacetophenone(81-14-1) |
| EPA Substance Registry System | Musk ketone (81-14-1) |
Product Usage
Musk Ketone serves as a prominent synthetic aromatic raw material and effective fragrance fixative. Within the flavor and fragrance sector, it is blended into assorted perfume compositions to deliver a unique, persistent musk note. It finds especially frequent application in sweet, oriental and rich heavy fragrance accords.
For cosmetic manufacturing, this ingredient is regularly added to perfumes, face powders, creams and other analogous finished goods. It elevates the integrated aroma harmony and extends the retention time of scent upon the skin surface.
Moreover, its adoption within pharmaceutical scenarios remains restricted over toxicity risks and environmental worries. Nevertheless, pharmacological research reveals its bioactive impacts: it can excite the central nervous system, respiratory center and cardiac tissues. It may also boost glandular secretion, expand coronary vessels to raise coronary perfusion, and support better blood circulation, edema alleviation and pain relief.
